I had this info scattered around in many posts, I thought I would put it all here for a generic checklist when setting up a new mining rig, no matter what you are mining.

Lets start with bios:

Set power to resume at latest state so if your electricity goes out, it will start up again.
Set boot beep on.

Install Windows 10 x64

Install the latest stable AMD Radeon Crimson Drivers:

http://support.amd.com/en-us/download/desktop?os=Windows+10+-+64

The latest stable version for me is 16.12.1

Install Awesome Miner, or rather the Remote Agent if this is a mining node:

http://www.awesomeminer.com/

Setup Virtual Memory to 16 or 32 GB:

16 GB: 16384 MB
32 GB: 32768 MB

Control Panel
System and Security/System
Advanced system settings
Advanced (Tab)/Performance/Settings (Button)
Advanced (Tab)/Virtual Memory/Change (Button)
Uncheck "Automatically manage paging file size for all drives"
Click "Custom Size"

If you can do 32, do it, otherweise 16 would be ok:
Min: 32768
Max: 32768

Click "Set" and get out of all the dialogs...

You may have to reboot.

Reboot straight into mining:

Auto login:

netplwiz

Set Awesome Miner to start on reboot.
Set your managed miner to start on reboot.

Lock after login: (Optional if your rigs are secure)

rundll32.exe user32.dll,LockWorkStation

Other Software you may want to install:

Chrome

https://www.google.com/chrome/browser/desktop/index.html

Notepad++

https://notepad-plus-plus.org/

TortoiseSVN

https://tortoisesvn.net/downloads.html

Other Settings you may want to adjust:

Give your computer a name

Allow Remote Access

Power Options
    Turn off display: Never
    Put Computer to sleep: Never

Windows Folder defaults:
    Unhide known extensions
    Unhide system folders

Set your time zone

Never get stuck after a windows crash. Run this as administrator: (This removes the prompt and always reboots normally into windows)

bcdedit /set {current} bootstatuspolicy ignoreallfailures

Remove the popup after a crash: (Sometimes a mining crash has a modal alert waiting for you to hit “OK”)

gpedit.msc

Navigate to:
  Computer Configuration
  Administrative Templates
  Windows Components
  Windows Error Reporting

Double click on "Prevent display of the user interface for critical errors"

Set to Enabled

Exclude your Mining Software folders from Windows Defender. Don’t let Defender take down your whole mining operation by quarantining your mining software:

C:\common\apps (or wherever)
C:\Users\YourUserName\AppData\Roaming\AwesomeMinerService

Using Wattman, your values may have to be tweaked depending on the silicone lottery:

Memory: 2200mhz (overclocked), 975mv (underclocked)
Power Limit: +15%

This will draw 825w from the wall with 3 cards.

Stock for these cards are:

Memory: 2000mhz, 1000mv
Power Limit: 0

In the Claymore Miner config.txt:

-ethi 8
-dcri 60

I left the Core clock at stock which is defaulted to 1266 or 1288 (XFX version)

More can be done with tweaking the Core Clock, but my 850w power supply was already at 825w with 3 cards and motherboard/fans.

Installing another power supply for 3 more cards will let me tweak the numbers some more.

With the settings above, I was able to get:

ETH/ETC: 27 Mh/s (26 Mh/s on one of the cards)
DCR: 810 Mh/s (790 Mh/s on one of the cards)

Heat and Fans:

Max: 80 C
Target: 75 C

This build deals with setting up Windows 10 to mine Ethereum and Decred, using the RX 480 GPU.

Install Windows 10 x64
—-
Install the latest AMD Radeon Crimson Drivers

http://support.amd.com/en-us/download/desktop?os=Windows+10+-+64

Crimson Edition 16.7.3 (Main installer, run this.)

After Crimson is installed, then do an update within Crimson. You will then be at “Crimson Edition 16.8.3” (or later)
—-
Install AwesomeMiner

http://www.awesomeminer.com/

—-
Configure Claymore ETH/DCR

New Miner Wizard
—-
Example of config.txt for mining ETC (Ethereum Classic)

-r 1
-ethi 8
-dcri 60

-etha 0
-mode 0

-gser 2

### ETC ########################################
-epool us1-etc.ethermine.org:4444
-ewal 0xBAf5706B333F709211Ab5A2A5669970A55385934.YourMinerName
-esm 0
-epsw x
-allpools 1
-allcoins 1

### DCR ########################################
-dpool stratum+tcp://dcr.suprnova.cc:2252
-dwal YourUserName.YourMinerName
-dpsw YourPassword

Example of config.txt for mining ETH (Ethereum)

-r 1
-ethi 8
-dcri 60

-etha 0
-mode 0

-gser 2

### ETH ########################################
-epool us1.ethermine.org:4444
-ewal 0x7563A2D88F2151B659F22FAd213E3A0E6fedE943.YourMinerName
-esm 0
-epsw x
-allpools 1
-allcoins 1

### DCR ########################################
-dpool stratum+tcp://dcr.suprnova.cc:2252
-dwal YourUserName.YourMinerName
-dpsw YourPassword

Example of epools.txt

POOL: etc-eu.suprnova.cc:3333, PSW: YourPassword, WORKER: YourUser.YourMiner, ESM: 0, ALLPOOLS: 1
POOL: us1.ethermine.org:4444, PSW: YourPassword, WORKER: 0x57f57167a82da3de4e69de73d1bc9c731cdcbaf8.YourMiner, ESM: 0, ALLPOOLS: 1
POOL: us1.ethpool.org:3333, PSW: YourPassword, WORKER: 0x57f57167a82da3de4e69de73d1bc9c731cdcbaf8.YourMiner, ESM: 0, ALLPOOLS: 1

Example of dpools.txt

POOL: dcr.suprnova.cc:2252, PSW: YourPassword, WORKER: YourUser.YourMiner, ESM: 0, ALLPOOLS: 1
POOL: dcr.coinmine.pl:2222, PSW: YourPassword, WORKER: YourUser.YourMiner, ESM: 0, ALLPOOLS: 1
POOL: dcr.pool.mn:4722, PSW: YourPassword, WORKER: YourUser.YourMiner, ESM: 0, ALLPOOLS: 1

—-
How to reboot straight into mining:

Setup Autologin In Windows.

Lock after login:
rundll32.exe user32.dll,LockWorkStation

Set Awesome Miner to start on reboot.
Set your managed miner to start on reboot.
—-

Other Software you may want to install:
—-
Install Chrome
—-
Install Notepad++
https://notepad-plus-plus.org/
—-
Install TortoiseSVN
https://tortoisesvn.net/downloads.html
—-

Other Settings you may want to adjust:

Allow Remote Access
Power Options
    Turn off display: Never
    Put Computer to sleep: Never
Auto login: netplwiz
Windows Folder defaults:
    Unhide known extensions
    Unhide system folders

Never get stuck after a windows crash. Run this as administrator:

bcdedit /set {current} bootstatuspolicy ignoreallfailures

Remove the popup after a crash

gpedit.msc

Navigate to:
Computer Configuration/Administrative Templates/Windows Components/Windows Error Reporting

Double click on "Prevent display of the user interface for critical errors"

Set to Enabled